• MG-132: Proteasome Inhibition as a Precision Tool for Apo...

  2025-09-27

  Discover how MG-132, a potent proteasome inhibitor peptide aldehyde, enables advanced analysis of ubiquitin-proteasome system inhibition, apoptosis, and autophagy. This article presents a unique, mechanistic perspective on MG-132's role in dissecting cellular proteostasis and neurodegenerative disease pathways.

• ARCA EGFP mRNA: Next-Gen Controls for Quantitative Mammal...

  2025-09-26

  Discover how ARCA EGFP mRNA, an advanced enhanced green fluorescent protein mRNA with co-transcriptional capping, sets new standards for quantitative fluorescence-based transfection assays and mammalian cell gene expression studies. This in-depth analysis explores mechanistic insights, comparative technology, and emerging delivery strategies.

• Bortezomib (PS-341): Illuminating Proteasome Inhibition a...

  2025-09-25

  Explore how Bortezomib (PS-341), a reversible proteasome inhibitor, uniquely advances cancer research by linking 20S proteasome inhibition with the regulation of pyrimidine salvage pathways. This article offers a deeper mechanistic perspective on proteostasis and apoptosis, differentiating itself through integration of recent mTORC1–UCK2 findings.

• ISRIB (trans-isomer): Unlocking Translational Control in ...

  2025-09-24

  Discover how ISRIB (trans-isomer), a leading integrated stress response inhibitor, redefines research into ER stress, apoptosis, and cognitive enhancement. This article provides an in-depth exploration of ISRIB’s mechanistic advances and novel applications, setting it apart from previous reviews.

• KU-60019: Metabolic Vulnerabilities of ATM Inhibition in ...

  2025-09-23

  This article explores KU-60019, a potent ATM kinase inhibitor, emphasizing its dual impact on DNA damage response and metabolic adaptation in glioma models. We highlight emerging evidence of metabolic vulnerabilities induced by selective ATM inhibition, offering new perspectives for cancer research.

• Adiponectin belongs to the CTRP C

  2025-03-03

  

  Adiponectin belongs to the CTRP (C1q/TNF-related protein) superfamily. Except for adiponectin, 15 additional members have been identified (CTRP1-15) (Schaffler and Buechler, 2012). Of all the CTRPs, CTRP9 has the highest identity to adiponectin in globular domain (Wong et al., 2009). The structure o

• We have previously shown that the

  2025-03-03

  

  We have previously shown that the human gonadotropins hLH and hCG trigger a partly irreversible stimulation of intracellular cyclic AMP accumulation in mouse Leydig Tumor cyp450 inhibitors (MLTC) in contrast to all other tested mammalian LHs and CG (Klett et al., 2016). In order to get a better ins

• The A b action occurs in conditions where high

  2025-03-03

  

  The A2b action occurs in conditions where high concentrations of adenosine is generated, so its blockage does not interfere with other physiological processes mediated by adenosine and others AR [105]. Furthermore the A3 receptor was shown to have pro-apoptotic effects on tumor lines of breast, lung

• br Conclusions br Conflicts of

  2025-03-03

  

  Conclusions Conflicts of interest Acknowledgements This work was supported by Ege University Research Fund [BAP, 14-ECZ-030, 2016]. Introduction The interest in the effects of endocrine disrupting chemicals (EDCs) in the aquatic environment continues to increase over the past decade, sp

• On another hand pyrazoles are widely found as the

  2025-03-03

  

  On another hand, pyrazoles, are widely found as the core structure in a large variety of compounds of great biological and pharmaceutical value exhibiting anti-HCV [11], antitumor [12], cytotoxic[13], and antioxidant activities [14]. Finally, 1,2,3-triazoles have attracted the interest of medicinal

• Our previous work fails to

  2025-03-03

  

  Our previous work fails to show any maternal effect with blockade of 5-HT2A receptor, as acute and repeated treatment of MDL100907 does not alter maternal behavior at the behaviorally active doses (Chen et al., 2014). In the present study, MDL100907 pretreatment attenuated the maternal disruptive ef

• br Methods br Results br Discussion br Acknowledgements br

  2025-03-03

  

  Methods Results Discussion Acknowledgements This work was supported by the National Institutes of Health [Grant R21 NS081429], a Pilot Grant from the Vanderbilt Conte Center supported by the National Institutes of Health [Grant P50 M096972], and by the Department of Anesthesiology at V

• Compounds are representatives of an

  2025-03-03

  

  Compounds – are representatives of an array of MBG targets (, ) related to imidazole standard that were synthesized and initially tested in a rat CYP17 lyase screening assay (). The inhibitors were synthesized as racemates by coupling of 6,7-dimethoxy-naphthalene-2-isopropyl ketone with the requisi

• For the NSCLC patients with EGFR activating mutations EGFR

  2025-03-03

  

  For the NSCLC patients with EGFR-activating mutations, EGFR-TKIs (gefitinib and erlotinib) are effective clinical therapies [21], [22]. However, approximately 10% of patients harboring EGFR-sensitizing mutations exhibit intrinsic resistance, and up to 40% do not attain a major response to treatment

• Of note core autophagy factors also play an

  2025-03-03

  

  Of note, core autophagy factors also play an important role during the infection of host cells by another type of picornavirus, namely, echovirus 7. ATG16L1 was found necessary for entry/internalization into Caco-2 polarized epithelial cells because the virus accumulated on the surface of ATG16L1-de

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