• The so called driver hypothesis has been posited in

  2019-04-17

  

  The so-called driver SGX523 has been posited in the recent years. Optical mapping studies in isolated sheep hearts have suggested that at least some cases of AF can be maintained by high-frequency reentrant sources (rotors), usually located in the posterior LA, which result in spatially distributed

• The concept of metronomic chemotherapy began in the s when

  2019-04-17

  

  The concept of metronomic chemotherapy began in the 1990s, when Kerbel showed chemotherapeutic agents may be able to target tumor vessel endothelial cells. In 2000, Browder et al demonstrated a more frequent, lower dose of cyclophosphamide, i.e. anti-angiogenic schedule, could induce response in tum

• br Erythropoietin and the HSC niche Many molecules

  2019-04-17

  

  Erythropoietin and the HSC niche Many molecules produced both locally and systemically, including erythropoietin (Epo) and adrenergic catecholamines, also appear to affect HSC niche and metastatic lesions in the bone marrow. EPO is a hematopoietic hormone produced predominantly in the kidneys in

• Several cases of injury to the

  2019-04-17

  

  Several cases of injury to the circumflex artery owing to ablation of the lateral mitral isthmus and inside the CS have been reported. The circumflex artery and the CS share a close relationship. Takahashi et al. reported the first case of acute circumflex artery occlusion during CS ablation, which

• Es de todos conocido que durante el

  2019-04-17

  

  Es de todos conocido que durante el reinado de Felipe III y su privado, el duque de Lerma, la corrupción, el cohecho y la venta de cargos alcanzaron niveles inusitados. El desplome de la legalidad se sumó ahr inhibitor la crisis económica que venía arrastrándose desde el reinado de Felipe II. En 159

• br Implementation of a programme called the

  2019-04-17

  

  Implementation of a programme called the , the key component of the UNICEF/WHO Baby-Friendly Hospital Initiative (BFHI) increases exclusive breastfeeding at 3 months, any breastfeeding at 12 months, and reduces diarrhoeal disease. These outcomes were shown in a cluster-randomised study of 31 hospi

• Parte de las idas y vueltas ten an

  2019-04-17

  

  Parte de las idas y vueltas tenían que ver con la negociación de un convenio sobre cooperación científico-técnica (suscrito el 27 de agosto de 1980), de uno financiero por un préstamo de 30 millones de dólares (firmado entre el 19 y el 24 de noviembre de 1980 entre el Banco Central argentino y el Ba

• br Case report A year old

  2019-04-16

  

  Case report A 73-year-old man with HCM experienced palpitations for 6 months. A 12-lead electrocardiogram (ECG) obtained at a medical clinic showed a first-degree atrioventricular block (PR interval, 260ms), left ventricular hypertrophy (LVH) with strain-type negative T waves in V2–6 leads, and m

• br To see how the quantity of osteosarcoma

  2019-04-16

  

  To see how the quantity of osteosarcoma in vitro studies developed overtime, we set out to systematically identify all the drugs that have been tested on osteosarcoma GSK2118436 in vitro in the past two decades. A PubMed search strategy was compiled which can be found in Supplementary data 1. To

• Treatment options for elderly AML must be based

  2019-04-16

  

  Treatment options for elderly AML must be based on four main factors: patient\'s clinical condition, disease characteristics, patient wishes and social support. Thus, the most frail and oldest among the oldest will have the least net benefit from chemotherapy or hematopoietic transplantation, even i

• People in LMICs are disproportionately exposed to severe acu

  2019-04-16

  

  People in LMICs are disproportionately exposed to severe acute kidney injury and have substantially less access to effective treatment than do people in higher-income countries. Framing acute kidney injury as a driver of substantial inequity in disease risk and mortality in low-resource countries, t

• Nonaka et al have described that the right

  2019-04-16

  

  Nonaka et al. have described that the right diaphragm is greatly elevated, the left ventricle tends to move vertically, and the ascending glucokinase moves to the right side after a right upper lobectomy [9]. In this patient, it was unknown whether the right upper lobectomy resulted in the observed

• The patient underwent surgery on December A cm

  2019-04-16

  

  The patient underwent surgery on December 2, 2013. A 13 × 13 cm elastic lobulated yellowish tumor, arising from the upper jejunum with suspected local invasion into the transverse colon and mesentery, was detected intraoperatively. Thus, small bowel segmental resection and left hemicolectomy were pe

• Pharmacokinetics analysis of AT on SCID mice bear

  2019-04-16

  

  Pharmacokinetics analysis of AT-406 on SCID mice bearing MDA-MB-231 tumors has shown that AT-406 achieves a maximum concentration in plasma between 1.5μM and 9.9μM, and a maximum concentration in tumor tissue between 0.5μM and 18.2μM, depending on the dose and administration route (intravenous versu

• PCP inhibitor Introduction Despite advances in breast cancer

  2019-04-16

  

  Introduction Despite advances in breast cancer treatment, bone remains the most common site of PCP inhibitor [1,2] occurring in around 70% of patients with metastatic disease [3]. Bone metastases are incurable and associated with significant morbidity in terms of fractures, pain, and reduced quali

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