• br Future perspectives Understanding how peptides are degrad

  2021-03-22

  

  Future perspectives Understanding how peptides are degraded, particularly those which may be therapeutically useful, such as GLP-1, has proved to be invaluable in providing a rationale for the development of a novel class of therapeutic agents. However, while DPP-4 plays an important role in the

• br Introduction Plasmodium falciparum malaria continues to b

  2021-03-22

  

  Introduction Plasmodium falciparum malaria continues to be a major global cause of mortality and morbidity. Malaria treatment and control has been complicated by the emergence of resistance to widespread antimalarial drug use. The most common method for measuring antimalarial resistance is estima

• MTX and MTXPGs block the activity of the

  2021-03-22

  

  MTX and MTXPGs block the activity of the key enzyme DHFR (Fig. 1), which converts folates to their active forms – dihydrofolate (DHF) and tetrahydrofolate (THF). MTXPGs also potently inhibit thymidylate synthase (TS). Furthermore, during dTMP synthesis, TS utilizes the cofactor 5,10-methylene THF, w

• br The contribution of Interference RNA and epigenetic

  2021-03-22

  

  The contribution of Interference RNA and epigenetic in OA attenuation Interference RNA, a cellular mechanism for post-transcriptional gene silencing that is associated with mRNA. The potential of RNAi has successfully silenced the wide range of protein coding genes. Its high specificity sanctions

• br Introduction The discoidin domain receptors DDRs

  2021-03-22

  

  Introduction The discoidin domain receptors (DDRs), DDR1 and DDR2, are unique among the receptor tyrosine kinases (RTKs) in being activated by interaction with the extracellular matrix [1], [2]. Binding to triple-helical collagen is mediated by the receptor extracellular domains that include an N

• In addition to an action via P Y

  2021-03-22

  

  In addition to an action via P2Y receptors, extracellular UDP activates GPCRs for cysteinyl leukotrienes (CysLT1, CysLT2; Mellor et al., 2001, 2003). GPR17 has been reported to function as a receptor for cysteinyl leukotrienes and uracil nucleotides (Boda et al., 2011; Fumagalli et al., 2011; but se

• Methylated CpGs can recruit transcriptional

  2021-03-22

  

  Methylated CpGs can recruit transcriptional co-repressors to prevent transcription factors (TFs) from promoting gene expression by tightly packing (R,S)-Anatabine synthesis structures [38]. Two CpG islands in the IPT5b promoter region showed higher methylation level in M9 rootstock compared to Mr (

• fasudil For any vector let and

  2021-03-22

  

  For any vector , let , and . For , let The information matrix for the partial likelihood at Eq. (2.2) can be expressed as It is well known that fasudil under certain regularity conditions such as (A)–(D) in Andersen and Gill (1982), where and denote the maximum likelihood estimator from Eq. (

• br Author contributions br Funding M E B

  2021-03-22

  

  Author contributions Funding M.E.B. was supported by Research Fund #3096. Competing interests Introduction Lung cancer has become one of the most common death causes in both male and female malignant tumors (Jemal et al., 2011). Air pollution, smoking and estrogen level are known risk f

• Senegenin Recently roflumilast has been approved as the firs

  2021-03-22

  

  Recently, roflumilast has been approved as the first selective PDE4 inhibitor for the treatment of chronic obstructive pulmonary disease (COPD) [2]. Roflumilast has been suggested to target several different pathogenetic mechanisms, including inflammation, fibrotic, emphysematous and vascular remode

• Introduction Pain is frequently the first clinical

  2021-03-19

  

  Introduction Pain is frequently the first clinical symptom of head and neck carcinoma. Indeed, pain is the initial reason leading ∼70% of cancer patients to seek professional assistance (Lam & Schmidt, 2011; Rettig & D’Souza, 2015; Schmidt, 2014). Clinically, cancer-induced facial pain can be evoke

• Our research has demonstrated that the

  2021-03-19

  

  Our research has demonstrated that the absolute bioavailability of oxymatrine, having a similar structure with OSC, was only 6.79±2.52%. About 50% of OSC was converted to its active metabolite SC in vivo; hence, the absolute bioavailability of OSC was speculated to be poor as well [24]. Understandin

• To elucidate whether the impact of hypoxia on EGFR

  2021-03-19

  

  To elucidate whether the impact of hypoxia on EGFR expression is cell context specific or culturing density dependent, we chose the following cancer XL184 synthesis driven by EGFR and evaluated the EGFR expression after hypoxia treatment at different culturing density: a highly aggressive and poorly

• Although PD is traditionally viewed

  2021-03-19

  

  Although PD is traditionally viewed as a motor disorder, evidence from numerous epidemiologic (Shiba et al., 2000) as well as case–control studies (Richard, 2005) suggest the occurrence of non-motor symptoms including hyposmia/anosmia, gastrointestinal disturbances, sleep abnormalities, autonomic dy

• s1p receptor Some family I DNA ligases

  2021-03-19

  

  Some family I DNA ligases can use dATP as nucleotide cofactor. For instance, human s1p receptor I uses dATP with a catalytic efficiency that is only 36-fold lower in comparison to ATP [9]. EhDNAlig is unable to use dATP as a nucleotide cofactor, indicating a more constrained active site in comparis

15437 records 665/1030 page Previous Next First page 上5页 661662663664665 下5页 Last page