• Besides its established insulinotropic actions GIP has been

  2021-11-04

  

  Besides its established insulinotropic actions, GIP has been shown to possess other direct beneficial effects on the beta cell, including stimulation of growth, differentiation, proliferation and survival.21, 22, 23 It has also been shown to stimulate proinsulin gene transcription and translation. M

• The general aim of our

  2021-11-04

  

  The general aim of our in vitro experiments was to analyze the patterns of ghrelin and GHSR-1a expression in the mammary glands of dairy goats during pregnancy and to examine the direct effect of ghrelin on cell proliferation in cultured MECs of pregnant dairy goats. For this purpose, we cultured go

• erk pathway Interestingly we have shown that OA required

  2021-11-04

  

  Interestingly, we have shown that OA required FFAR4 to induce osteoblast gene expression in MC3T3-E1 pre-osteoblasts, but not to inhibit osteoclastogenesis in RAW264.7 murine macrophages. As previously suggested, FFAR1 may mediate the effects of OA in osteoclasts. However, FFAR1 has also been shown

• br Introduction The fibroblast growth factor receptor FGFR p

  2021-11-04

  

  Introduction The fibroblast growth factor receptor (FGFR) pathway is an important oncogenic driver in malignant cancer. It controls cellular processes such as cell proliferation, differentiation, migration, cyclin dependent kinase progression, metabolism, and survival. In non–small-cell lung canc

• The activation of GPR FFA signaling triggers the PLC

  2021-11-04

  

  The activation of GPR40/FFA1 signaling triggers the PLC/PIP2 signaling pathway and results in Ca2+ release from the endoplasmic reticulum (ER). Increased Ca2+ levels may lead to activation of different protein kinases, such as Ca2+/calmodulin-dependent protein kinase type IV, Akt, extracellular sign

• GPR levels were not changed by any

  2021-11-03

  

  GPR40 levels were not changed by any treatment. GPR40 has the same agonists as GPR120 but only a 10% homology [35] despite using the same intracellular signaling cascades [7]. Previous data on the ability of exercise to modulate G protein coupled receptors in general are scarce. The long-chain fatty

• Considering that loss of LAG expression results in increased

  2021-11-03

  

  Considering that loss of LAG-3 BV6 results in increased CD4+ T cell homeostatic expansion, and that the ability of a cell to proliferate is tightly coupled to its metabolic profile, we hypothesized that LAG-3 regulates naive CD4+ T cell metabolism. Our results indicate that, indeed, Lag3-deficient

• Being a facultative intracellular pathogen C pseudotuberculo

  2021-11-03

  

  Being a facultative intracellular pathogen, C. pseudotuberculosis is exposed to oxygen and nitrogen species (ROS and RNS, respectively) reactive environment within macrophages (Nathan and Shiloh, 2000), apart from species endogenously generated by metabolic processes. These molecules interact with D

• We also observed a significantly higher SLC

  2021-11-03

  

  We also observed a significantly higher SLC10A1 gene expression and NTCP protein level among metastatic individuals vs. donor livers. Na+/taurocholate co-transporting polypeptide (NTCP), which is expressed on the basolateral membrane of hepatocytes and is primarily responsible for the uptake of bile

• Glial cells have emerged as

  2021-11-03

  

  Glial cells have emerged as important protagonists of the central nervous system (CNS) physiology (Chen and Swanson, 2003; Kettenmann and Verkhratsky, 2008; Parpura and Verkhratsky, 2012). As widely described in the literature, astrocytes regulate glutamatergic synapses by clearance of glutamate in

• br Materials and methods br

  2021-11-03

  

  Materials and methods Results Discussion In nerve terminals, Na+-dependent glutamate transporters of the plasma membrane are responsible for the maintenance of low (non-toxic) extracellular glutamate concentrations and accomplish uptake of glutamate into the SRT1720 of neurons and glial ce

• Here we reported series of carbohydrate modified

  2021-11-03

  

  Here, we reported series of carbohydrate-modified compounds containing a dibromo substituted benzene ring which was derived from the red alga (). The conformation flexibility of bcr-abl inhibitors and their polyol structures give them many unique biological properties as we have described earlier. M

• br Materials and methods br Results The immunoblot analysis

  2021-11-03

  

  Materials and methods Results The immunoblot analysis demonstrated the presence of similar immunoreactivity by liver FBPase in hepatic and renal extracts. These results indicate that FBPase is present in a similar amount in both tissues. Moreover, the analysis revealed that the antibody detect

• Introduction RNA splicing occurs in the nucleus when noncodi

  2021-11-03

  

  Introduction RNA splicing occurs in the nucleus when noncoding sequences (introns) are removed from the pre-mRNA transcript and coding sequences (exons) are joined to form a mature mRNA [1,2]. This reaction is catalyzed by a multiprotein complex called spliceosome. The spliceosome consists of five

• rapamycin price Plasmid construction and site directed

  2021-11-03

  

  Plasmid construction and site-directed mutagenesis of M. luteus B-P 26 UPS. For the expression of N-terminus His6-tagged M. luteus B-P 26 UPS, the expression plasmid pMluUEX [7] was cleaved with the restriction enzymes NdeI/BamHI. The gene fragment was inserted into an NdeI/BamHI-treated pET-15b to

16185 records 577/1079 page Previous Next First page 上5页 576577578579580 下5页 Last page