• G has been shown to participate in various MT

  2023-12-28

  

  Gβγ has been shown to participate in various MT-dependent processes such as cell growth and differentiation [15,[21], [22], [23], [24], [25], [26]]. G-protein β-subunit anti-sense oligonucleotides have been shown to inhibit cell proliferation and cause disorganization of the mitotic spindle in mamma

• AMPK modulates changes in lipid metabolism

  2023-12-28

  

  AMPK modulates changes in lipid metabolism via the regulation of fatty Rosiglitazone maleate oxidation and cholesterol synthesis in the liver. The key enzymes involved include ACC and HMGCR [27,28]. Both participate in the rate-limiting steps of fatty acids and cholesterol synthesis and are inactiv

• fluvastatin sodium synthesis br Acknowledgments We thank the

  2023-12-28

  

  Acknowledgments We thank the anonymous reviewers for their constructive comments on the manuscript, and also thank Dr. Hans-U. Dahms for his comments on the manuscript. This work was supported by a grant from the National Research Foundation (2009-0071218) funded to Young-Mi Lee. This work was al

• For the NSCLC patients with EGFR

  2023-12-27

  

  For the NSCLC patients with EGFR-activating mutations, EGFR-TKIs (gefitinib and erlotinib) are effective clinical therapies [21], [22]. However, approximately 10% of patients harboring EGFR-sensitizing mutations exhibit intrinsic resistance, and up to 40% do not attain a major response to treatment

• Beside estrogen several classes of compounds have shown sign

  2023-12-27

  

  Beside estrogen, several Pyridone 6 of compounds have shown significant neuroprotective efficacy when administered shortly after the induction of animal models of stroke, including glutamate (NMDA) receptor antagonists and zinc chelators [25], [26], [27]. Effects of these or other neuroprotective a

• According to the present observations the Ampk isoform

  2023-12-27

  

  According to the present observations, the Ampkα1 isoform promotes AP-1 transcriptional activity and thereby fosters nmda receptor antagonist of AP-1 target genes in cardiomyocytes via activation of Pkcζ. The transcription factor AP-1 plays a decisive role during cardiac remodeling [24], [25], [26]

• It was deduced empirically that

  2023-12-27

  

  It was deduced empirically that the helix direction of the COOC torsion might relate to the sign of the peroxide Cotton effect. Huang reported ab initio calculation of the peroxide bond using MRDCI method and DZP basis set, but only the fragment CH3OOCH3 instead of full molecule was studied [19]. Si

• The initial demonstration of the

  2023-12-27

  

  The initial demonstration of the potential of MALDI-TOF MS for testing antifungal susceptibility of pathogenic fungi came from a proof-of-concept study by Marinach et al. [31] who monitored the changes of the proteome of C. albicans IU1 exposed to different concentrations of fluconazole. Using a rig

• arn 509 receptor Not all secondary metabolites or natural pr

  2023-12-27

  

  Not all secondary metabolites or natural products can be fully synthesized due to their very complex structures that are too difficult and expensive on industrial scale. Hence, there is an urgent need to search for alternative remedies as naturally occurring biologically active secondary metabolites

• br Acknowledgements br Introduction Diabetic complications a

  2023-12-27

  

  Acknowledgements Introduction Diabetic complications are responsible for increased morbidity and mortality of diabetic patients. Increased flow of LY2409881 through the polyol pathway under conditions of hyperglycemia contributes to the development of diabetic complications. Aldose reductase

• In conclusion we show that

  2023-12-27

  

  In conclusion, we show that HBP1 is phosphorylated on three sites, which control HBP1 transcriptional activity and glioblastoma cell proliferation. This phosphorylation largely depends on AKT, although other kinases may also be involved. In a previous study, we had shown that the PI3K-AKT pathway re

• Extracellular ATP and downstream purinergic signaling

  2023-12-26

  

  Extracellular ATP and downstream purinergic signaling have also been proposed to contribute to dental pulp tissue healing and dentin regeneration. Mechanical and thermal stimulation of external dentin can induce ATP release in dental pulp through pannexins [13]. Cold stimulation was also reported to

• The AChR is composed of five

  2023-12-26

  

  The AChR is composed of five homologous, membrane-spanning subunits. AChRs containing two α, one β, one δ and one γ subunit (AChRγ) predominate during embryonic development and mice lacking AChRγ die at birth (Takahashi et al., 2002). After birth, the AChRγs are replaced during the first 2 postnatal

• Recently biosensors based on enzyme

  2023-12-26

  

  Recently, biosensors based on enzyme-mimicking organic-inorganic hybrid nanomaterials such as protein or DNA-Cu nanoflowers (Batule et al., 2015, Park et al., 2017), Fe-aminoclay (Lee et al., 2013), and MOFs (Ai et al., 2013, Dong et al., 2015, Feng et al., 2012, Liu et al., 2013, Qin et al., 2013,

• br Conclusion There have been multiple clinical trials and p

  2023-12-26

  

  Conclusion There have been multiple clinical trials and pre-clinical studies that have tested the utility of 5ARIs in treating prostate disease, as summarized in Fig. 1. Inhibiting androgen action through the use of finasteride and dutasteride has been established as a valuable resource for physi

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