• Our results lead to the discovery and characterization

  2024-03-05

  

  Our results lead to the discovery and characterization of VvAAT2, a gene potentially involved in acetate accumulation in grape berries discovered through amino-acid feeding experiments. Incubation with exogenous amino acids has also been a key in the discovery of new genes affecting fruit aromas [13

• The proposed formulation is however challenging to

  2024-03-05

  

  The proposed formulation is, however, challenging to solve since the structured sparsity-inducing norms are non-smooth. In order to solve the new objective function, we consider two different approaches: proximal averaging, which takes the average the solutions from the proximal operator for the ind

• The fat body is one of the largest

  2024-03-05

  

  The fat body is one of the largest tissues of Bombyx mori, with components including fat, glycogen, protein and vitamins. The fat body exhibits important physiological functions, not only storing a large number of nutrients but also serving as an important site of biosynthesis and metabolism (Arrese

• suramin Polycyclic aromatic hydrocarbons PAHs are abundant e

  2024-03-04

  

  Polycyclic aromatic hydrocarbons (PAHs) are abundant environmental contaminants that are produced by the incomplete combustion of organic matter, combustion engines, residential heating, suramin burning, and industrial activities (Gelboin, 1980; Phillips, 1999, Phillips, 2002). Some PAHs have been

• PAN induced nephrosis was accompanied

  2024-03-04

  

  PAN-induced nephrosis was accompanied by loss of body weight, decrease of food intake, increase in urine volume and increases in triglycerides and cholesterol levels, which have been reported previously (Natori et al., 1996). Except for urine volume, each one of these measures was improved by A-3069

• As shown in B the recombinant human LOX nM showed

  2024-03-04

  

  As shown in B, the recombinant human 15-LOX-1 (30nM) showed a time-dependent increase in fluorescent signal, and signal development was almost completed within 20min in the presence of 50μM arachidonic BINA and 5μM DHR. For both purified enzyme and cell lysates, the enzyme activities disappeared wi

• Therefore the rational design of target compounds is

  2024-03-04

  

  Therefore, the rational design of target compounds is based on the hybrid of attractive phenotypic bis-indole (5, Fig. 1) and sulfonamide moieties, in which the indole core might anticipate in hydrophobic interaction, and the functionality of sulfonamide group may involve in H-bonding with the site

• Here the so called alkali assay is proposed as

  2024-03-04

  

  Here the so-called alkali assay [18] is proposed as a method to be applied directly on the purified recombinant enzyme sharing the same structural and functional features of the wild-type enzyme [19], [20], [21] using its physiological substrate androstenedione. The assay that was already successful

• TLRs play a key role

  2024-03-04

  

  TLRs play a key role in pathogen recognition and early response. In our study, we showed an increase of TLR2 mRNA and protein expression after BMECs were stimulated by S. aureus, as seen for BMECs in a previous study [25]. Although most studies describe TLR4 as a primary receptor for Gram-negative b

• In humans the superior safety profile of lipid

  2024-03-04

  

  In humans, the superior safety profile of lipid-associated formulations is characterized by decreased acute infusion-related reactions and dose-related nephrotoxicity, allowing the administration of larger doses and therefore similar efficacy with fewer administrations. In vitro studies and human cl

• br Steroidogenesis in the skin The

  2024-03-02

  

  Steroidogenesis in the skin The synthesis of steroid hormones takes place in many tissues of which the adrenal glands, ovaries, testis, placenta and p2x7 antagonist are considered to be classical steroidogenic organs. Nevertheless, skin constitutes an important peripheral steroidogenic tissue. St

• Because of the critical roles played

  2024-03-02

  

  Because of the critical roles played by AMPK in energy sensing and cancer cell survival, a huge number of drugs have been proposed to exert their pharmacological effects by means of AMPK activation (Kim and He, 2013). For example, metformin has been shown to activate AMPK in muscle (Sajan et al., 20

• Bioinformatics tools are becoming more powerful and

  2024-03-02

  

  Bioinformatics tools are becoming more powerful and reliable due to the growing number and availability of experimentally determined protein structures (Arnold et al., 2006, Suplatov et al., 2015, Wiltgen and Tilz, 2009). The SWISS-MODEL and MODELLER programs are most frequently used for homology or

• br HIF HIF signaling in

  2024-03-02

  

  HIF-1α HIF-1α signaling in cancer cells contributes to tumor progression by promoting angiogenesis, invasion, metastasis, and the recruitment of immunosuppressive cells via secreted modulators 36, 37. One example of a HIF-1α immunosuppressive pathway is through increased expression of inducible n

• br Mechanisms for regulation of

  2024-03-02

  

  Mechanisms for regulation of intracellular cholesterol homeostasis Cells maintain intracellular free cholesterol levels and distribution within stringent tolerances by several mechanisms [55]: (1) uptake of native LDL (the major extracellular carrier of cholesterol) by LDL receptors and modified

15399 records 138/1027 page Previous Next First page 上5页 136137138139140 下5页 Last page